In order to get uniform water distribution, nozzle size selection of low pressure sprinklers with nonuniform spacing along the center pivot main lateral was established.Three configuration methods of sprinklers equipped with, without and partly with pressure regulators were put forward, and databases on sprinklers, pressure regulators and spans were built. Software on nozzle configuration and hydraulic performance analysis of center pivot irrigation system was also developed. Nozzle package selection for DYP—249 center pivot was generated by using the developed software and a field experiment on its hydraulic performance was conducted. The results showed that the inlet flow rate by using the software for DYP—249 center pivot was very close to the theoretical value, with a relative error less than 1.1%. Both the measured and simulated application rates along the main lateral had the same change trend. Due to the wind speed, wind direction, evaporation and drift, programming algorithm etc., the measured water distribution coefficient was 75.26%, lower than the simulated coefficient of 85.59% by this software. The practical example showed that the software could achieve quick and accurate nozzle configuration, and well predicted hydraulic performance for center pivot irrigation system.