In order to predict the performance of deep-well centrifugal pump quickly and accurately by the commercial CFD software Fluent, 150QJ20 type deepwell centrifugal pump was taken as an experimental object to research the key set methods on the Fluent simulation. The numerical simulation was carried out at different grid numbers, different residual convergence precisions, different turbulence models, and different flow calculation methods to analyze the impact on simulation results. And different stages of the deep-well centrifugal pump model simulations were analyzed and discussed. The best set methods of numerical simulation for deep-well centrifugal pump were selected. The differences between numerical simulation and experimental results were compared and analyzed. This work is real significance in understanding the accuracy for deep-well centrifugal pump, and it confirmed the feasibility of predict the performance of deep-well centrifugal pump by using Fluent.