Evaluation of comprehensive benefit was conducted in greenhouse muskmelon under aeration irrigation by applying comprehensive evaluation method, which associated entropy information method based on objective weighting with subjective weighting method. Results showed that the comprehensive benefit order in every treatment was once per two days, once per day, none aeration, once per three days, twice per day, and furrow irrigation treatment. Aeration irrigation could improve yield and quality of greenhouse muskmelon differently, but the comprehensive benefit of some aeration treatments decreased because of the investment of electricity, drip facility, et al. The comprehensive benefit of greenhouse muskmelon in subsurface irrigation treatment was better than in furrow irrigation treatment. 