A CAD/CAE integration analytical method of machine tool mechanism was proposed based on the 3-D design software SolidWorks and the finite element analysis software ABAQUS, the CAD/CAE integration and automatic computation were realized by integrating the parametric modeling function of CAD and the finite element analysis function of CAE. Stepwise regression modeling based on Latin hypercube sampling and CAD/CAE integration was also proposed to improve the modeling efficiency of machine tool structural performance, it could reduce the samples and ensure the modeling accuracy by monitoring the stepwise regression model. The CAD/CAE integration analysis and stepwise regression model were carried out on spiral bevel gear milling machine, and proved to be feasible. 