In order to explore the optimal combination of water and fertilizer for strawberry, nine treatments were set from three levels of irrigation and fertilizer, and the effects of different water and fertilizer coupling on yield, fruit quality, water and fertilizer utilization efficiency of strawberry were analyzed. The analytic hierarchy process (AHP) and entropy weighted multilayer empowerment on nine indexes from three kinds of factors were introduced, combination method which derive from game theory was used to obtain the single final target weight, the comprehensive growth evaluation system for strawberry based on TOPSIS method was constructed, and mathematical fertilizer response model was established with the goal of achieve high yield, high quality and high efficiency. The results showed that the effect of water and fertilizer coupling on the weight of fruit per unit area, yield, water use efficiency and fertilizer use efficiency of strawberry was very significant, but not on the quality. The single fruit weight of strawberry was the highest under mediumwater and highfertilizer irrigation. The strawberry yield and soluble sugar were the best under mediumwater and mediumfertilizer irrigation. The strawberry had the best sugaracid ratio and soluble protein content under lowwater and highfertilizer irrigation. The soluble solids content and fertilizer utilization efficiency of strawberry were the best under lowwater and mediumfertilizer irrigation. The vitamin C content of strawberry was the highest under lowwater and lowfertilizer irrigation. The strawberry had the highest water use efficiency under lowwater and mediumfertilizer irrigation. Comprehensively coordinated the various indicators, the highest weighted value was yield (02641) and the lowest was soluble protein content (00595); the comprehensive evaluation of multiple indicators for optimal water and fertilizer treatment was mediumwater and mediumfertilizer (T5). Analyzing the response model of strawberry comprehensive growth to the coupling of water and fertilizer, the singlefactor effects of irrigation amount and fertilization amount were parabola opening downward. When the irrigation amount code value was -023 (23751m3/hm2), the fertilizer amount code value was -002. (182588kg/hm2), the strawberry comprehensive score was the highest. Dividing the optimal closed loop interval of water and fertilizer coupling based on a comprehensive evaluation of more than 90%, the irrigation amount of 2268~2520m3/hm2, and the fertilization amount of 175988~186987kg/hm2 were the most beneficial to strawberry growth.