The marginalization of farmland is the progression from high to low net profit of farmland utilization, and the abandonment of farmland is its extreme expression. This research was based on the perspective of farmland parcelization while also taking into account the natural suitability of the farmland, farming conditions, opportunity costs, and other relevant factors. Using a stepwise algorithm, a multidimensional analysis on the various factors that influencing the marginalization of farmland was performed, which was followed by verification of the outcome of analysis using remote sensing image data to identify the main factors that influencing the marginalization of farmland. The results of natural suitability evaluation showed that areas with high suitable, medium suitable and low suitability were 18900km2, 14164km2 and 8881km2, respectively, and natural suitability was the basic condition that affected the marginal utilization of cultivated land. The adjustment of cultivated land with poor natural suitability would be restored to forest land, which was conducive to the restoration of the regions fragile ecology. The areas with highly convenient, moderately convenien and inconvenient were 10369km2, 21405km2 and 10171km2, respectively. It was an important way to improve the utilization efficiency of cultivated land to carry on comprehensive management to the cultivated land with high natural suitability and inconvenient cultivation. And the areas with high opportunity cost, medium opportunity cost and low opportunity cost were 11932km2, 16457km2 and 13556km2, respectively, and the utilization of cultivated land in the area of high opportunity cost in Mengjin County can maintain a high profit, so the abandonment of cultivated land was rare. Using an overlay analysis of the database statistics of farmland and reforested land, it was discovered that currently, natural suitability and farming conditions had a more significant influence on farmland marginalization in Mengjin County. The research results may be used as a reference to formulate a more effective farmland utilization policy locally in the future.