Panax notoginseng is a kind of precious medicine and mainly grown in Yunnan Province. Aiming to study the mechanical filling performance and optimize the cell hole size of precise Panax notoginseng seed metering device based on EDEM software. It is necessary to accurately establish the seed discrete element model of Panax notoginseng and define the contact parameters of simulation model in EDEM software. Reverse engineering technology was used. Based on bonded particle model, the seed discrete element model of Panax notoginseng was established in EDEM software. Combined with bench experiment and simulation experiment, the contact parameters were calibrated in EDEM software. The restitution coefficient between Panax notoginseng seed and ABS plastic was 0611 by the impact bounce test method. The static friction coefficient between Panax notoginseng seed and ABS plastic was 0473 by the inclined plane sliding test method. The rolling friction coefficient between Panax notoginseng seed and ABS plastic was 0067 by the inclined plane rolling test method. Based on the response surface optimization of quadratic orthogonal rotating combination test method, the optimal contact parameters between the Panax notoginseng seeds in EDEM simulation experiment were determined. The restitution coefficient, static friction coefficient and rolling friction coefficient between Panax notoginseng seeds were 0.492, 0.202 and 0.083 by stacking test method, respectively. The Wenshan Panax notoginseng seeds were chosen for seeding object. The precise Panax notoginseng seed metering device were selected for verification experiment. The qualified index, missing index and multiple index of seed filling were taken as the experiment indexes of seed metering device. Under the experiment conditions of different rotation speeds, the measured and simulated values of the experiment indexes were compared. The relative error of the experiment indexes was less than 5.0%. The results showed that the seed discrete element model of Panax notoginseng and contact parameters can be used in the simulation experiment. It provided basis for the research of precise seed metering device based on EDEM software.