The basic structure and principle of cotton-stalk combine harvester were introduced. Whole configuration, chassis structure and feed cutter mechanism were designed. The automation in harvest, cut up, collection load, unload, was achieved, by adopting the following methods: principle of lengthways symmetric configuration simplification of feed mechanism, and configuration of the roller cutter by cross symmetry in left and right. The result indicate that the process is reasonable with the good applicability, which accelerates the development of cotton-stalk large-scale utilization. 