A high voltage electrostatic spraying vehicle was developed to control locusts in agriculture and stockbreeding. The experiment of two-fluid spray nozzle was carried out and the relationship of control parameters was obtained. It was found out that the liquid flow and droplet diameter could be adjusted by changing the proportion between gas pressure and liquid pressure. Meanwhile, the integrated vehicle experiment was conducted to get vehicle characteristics and locust-killing effects. The experimental results showed that droplet diameter distribution and deposition distribution had two peaks in spraying direction, the locust-killing rate of the vehicle could reach 93%, and locust-killing effect with absorbing pesticide was better than that with touching pesticide.