A method for solving conflicts in multi-disciplinary design optimization was proposed. Nash game equilibrium theory was applied to model the relations between the design players, and the advantages were discussed respectively. This method allows that each discipline adopts its own design optimization technique, and then integrates within the frame of this method. At last, the validity of this method was proved via an experimental case. The results show that the method does not need systematic coordination, and the information communications among every discipline are convenient.