Using two-translation and two-rotation parallel mechanisms as major structure of the isolation mounting, and applying inverse-adaptive method at prime mover house spring-damping device, it realized multi-DOF vibration damping in the paper. The experimental prototype was designed with the platform based on discussing the problem of system design, theory and ADAMS simulation analyze. The results of simulation and prototype test indicated that the designing theory of the multi-DOF vibration damping platform is correct and appropriate.