In this paper, a driver model based on the driver's heading angle was set up, and with the application of Matlab/Simulink and C language, the driver-environment-vehicle closed-loop simulation model was developed. The model was simulated with the genetic algorithm(GA) toolbox on the Matlab platform. The model parameters' optimal values were obtained by an object function of the genetic algorithm, which comprehensive evaluation index considers the task performance, driver's physical workload and mental pressure. The simulation and experimental results showed that the design of model is reasonable, and the model can describe the driving character of the sophisticated driver.