A multi-body dynamic model of the full vehicle was established by using automatic dynamic analysis of mechanical systems (ADAMS) software. A PI controller has been designed for the vehicle stability control (VSC) system under Matlab environment. By way of defining some data exchange interfaces between two kinds of software, the control system has been combined with the full vehicle model and thus, the whole electricity and machine system close-loop simulation model was constructed. The dynamic response of vehicle with VSC system under various operating condition was simulated. The simulation tests indicated that the VSC system could obviously improve vehicle stability and route follow capability. The result of study provided one effective verification method for the performance of VSC system.