Establishment of advanced quality management information system is an important foundation that could build enterprise quality management efficiently. In consideration of enterprise informative, the “process method” and application of ISO 9000:2000 in practice, the system model has been established based on the process quality management pattern with IDEF0 and UML (unified modeling language) method. The quality management model based on process method has been put forward, and ISO 9000 process-based QMIS(quality management information system) has also been developed. At last the QMIS feasibility and effectiveness has been proved