Aiming at the problems of low cleaning rate of eggshell membranes, high energy loss and complex structure of device for collecting the eggshell membranes and eggshells in the current research, multi-aspirator device was designed. The influence of particle collision on the movement of eggshells and eggshell membranes particles was analyzed. Under the condition of different number of inlet baffles in the cleaning chamber, the motion trajectories of eggshells and eggshell membranes and the characteristics of flow field inside the multi-aspirator device were analyzed by using the method of CFD-DEM coupling. The analysis results showed that with the increase of air inlet baffles’ numbers, the airflow velocity of cross flow area in the cleaning chamber was increased, and the loss rate of eggshell membranes was decreased. There was no vortex in the outlet of the cleaning chamber, so as that the cleaning rate of eggshell membranes decreases caused by airflow hindering the falling eggshells was avoided. The orthogonal test method of two factors and three levels was applied, feeding flow rate and airflow velocity at the interface of the sucking fan were taken as test factors, and the loss rate and the cleaning rate of eggshell membranes were taken as evaluation indexes. The parameters of influencing factors were optimized and verified by tests. The results of tests were that when the feeding flow rate was 200g/s, the airflow velocity at the interface of the sucking fan was 5.5m/s, the loss rate of eggshell membranes was 9.4%, the cleaning rate of eggshell membranes was 96.3%, and the power of sucking fan was 330W. The results could provide foundations for the application of multi-aspirator device for collecting eggshells and eggshell membranes.