Based of a long-term tillage experiment from 2011 to 2017 in Henan Province, the RZWQM2 model was calibrated and validated. Effects of no-tillage on soil water storage at the depth of 0~100cm, nitrogen accumulation in aboveground and root, crop yield and nitrogen use efficiency of winter wheat in different precipitation patterns were analyzed. The simulated results showed that the nitrogen accumulation in aboveground and root and crop yield of winter wheat in different precipitation patterns were decreased successively in the order of wet year, normal year, and dry year. Compared with conventional tillage, the average soil water storage at the depth of 0~100cm under no-tillage was significantly increased by 11.3%, 12.9% and 16.9% in dry, normal and wet year at the whole growing stages of winter wheat, respectively. The aboveground nitrogen accumulation in dry year and root nitrogen accumulation from heading to harvest stage in normal year under no-tillage were both increased by 2.5% and 3.1% compared with conventional tillage, respectively. The nitrogen use efficiency under no-tillage was increased by 26.7%, 8.7% and 6.0% in dry, normal and wet precipitation patterns respectively compared with conventional tillage. However, compared with conventional tillage, N fertilizer using efficiency was increased by 11.7% in dry year, and decreased by 1.7% in wet year.