According to the lack of systematic organization and classification of combine harvester knowledge, it was difficult to obtain and apply it efficiently in design. The concept of equipment pedigree and pedigree topology map was used to manage the knowledge and construct the knowledge base system of combine harvester under the traction of the actual application demand of intelligent design of combine harvester. Combined with the characteristics and forms of agricultural machinery design knowledge, the design process was analyzed and expressed by using the hybrid representation method of production rules and frame representation, and the design system was established. It used Visual Studio 2015 as the development tool, under the environment of . Net, using ADO.Net technology, CATIA secondary development technology and SQL Server database, the combine harvester design knowledge, parametric models and other resources were integrated and organized to build the combine harvester knowledge base system. By means of human-computer interaction, the design system was systematized, and the functions of knowledge query, reasoning and editing were realized by using fuzzy query, inference engine and ADO.Net. In addition, system transferred the pushed knowledge to the associated parametric models. The parameters of the related parametric models were adjusted, the models under different needs were quickly built, the design time was cut down and the design efficiency was improved. The knowledge base system could save the time of knowledge acquisition and analysis through case analysis, the system was used to query, reason, push and transfer the knowledge to the models for driving. This method can realize the efficient application of knowledge, enhance the inheritance and reuse of knowledge, improve the design efficiency, and provide a general method for the design of combine harvester parts. It was applicable to the requirements of the development of combine harvester series products, and establish the basis for the construction of a special intelligent design platform for combine harvester.