The key of utilization of the ration feeding technique in ruminant-breeding industry is the research and application of ration mixers. In view of the practical application and popularization of the ration feeding technique in recent years in China, and in order to promote the development of animal husbandry, combining with the current situation of few self-dependent innovation of ration mixers in China, a combined-type ration mixer of drum and blade was designed. To explore the mixing performance and obtain the optimum parameters of the combined-type ration mixer of drum and blade, the method of quadratic regression orthogonal rotational combination design was adopted to conduct the experiment by the self-developed combined-type ration mixing experimental device of drum and blade. The experimental diet was composed of cornmeal, soybean meal, salt, corn silage and hay. Mixing time, filling rate, rotational speed of drum and gyrating radius of blade were chosen as experimental factors, and mixing uniformity and net power consumption were determined as evaluation indexes. The regression mathematical models between the experimental factor and the evaluation index were established and analyzed by Design-Expert software, then the optimization result was verified by experiment. The results showed that the descending order of effects of various factors on mixing uniformity was filling rate, rotational speed of drum, mixing time and gyrating radius of blade;the descending order of effects of various factors on net power consumption was mixing time, rotational speed of drum, filling rate and gyrating radius of blade;and the mixing uniformity was 92.98% and net power consumption was 32.618kJ under the condition that mixing time was 3.5min, filling rate was 66%, rotational speed of drum was 29r/min and gyrating radius of blade was 236mm. The research results could provide reference for the research and development, optimization design and parameter selection of ration mixers.