An air-and-screen cleaning unit test-bed combined with centrifugal air flow cleaning and rotary screening was developed. The basic structure and working principle of cleaning unit test-bed were discussed, and the main structural and operating parameters were determined. Experiments were carried out in order to find the relationship between cleaning performance and main factors, such as centrifugal fan rotating speed, screen rotating speed, screen surface type, and screw conveyor rotating speed. An orthogonal test and the method of comprehensive analysis were carried out to find primary and secondary factors affecting the cleaning performance, which were screen rotating speed, centrifugal fan rotating speed, screen surface type, and screw conveyor rotating speed. When the centrifugal fan rotating speed was 2200 r/min, the screen rotating speed was 60 r/min, screen surface type was diamond-shaped hole mesh screen with the long diagonal of 6.7 mm, short diagonal of 4.0 mm, the screw conveyor rotating speed was 1150 r/min, the optimum operation condition was obtained. 