A dynamic process management approach based on conditional design structural matrix was proposed. Considering the possibility of the conditional constraints during the design process, the conditional constraint model was constructed based on the references of the design knowledge and condition parameters, the conditional knowledge dimension was brought into the traditional DSM model, and then the 3D conditional DSM model was obtained. Using the dynamical superimposed conditional DSM view in the model mentioned above, the consequence of the reconstruction in the design process could be reconstructed again and again. The approach presented was finally used in the general variant design system supporting the vehicle CVJ shafts design process modeling, an example was provided and the results demonstrated the higher efficiency and automation degree of the approach presented.