Micro centrifugal pump has a wide range of applications in the field of medical and chemical sewage treatment, but it often faces the problem of wear in use. In order to explore the compound wear type and wear change of micro centrifugal pump under different particle volume fractions, based on the method of computational fluid dynamics and discrete element coupling, and the deformable abrasive wear Archard model and the deformable erosion wear Oka model, the particle-component collision ratio, wear distribution and evolution of centrifugal pumps under different particle volume fractions (2%, 4%, 6%, 8%, 10%, 12%) were studied. The results showed that when the particle volume fraction was near 4%, the impact ratio between impeller blade and volute showed different trends. The wear in centrifugal pump was mainly abrasive wear, and the parts with the most serious wear in the abrasive wear accounted for 68.5% of the total abrasive wear. With the increase of particle volume fraction, the abrasive wear at the volute changed from section Ⅷ to section Ⅰ, and the front and back ends of the volute wear successively. The high wear area of erosion wear was mainly concentrated in the impeller blade, accounting for 95.83% of the total erosion wear. The evolution law of erosion wear section at the volute was similar to the change law of abrasive wear, but the back end of the volute was worn first. The particle volume fraction had more influence on the abrasive wear deformation of volute, and the abrasive wear deformation of volute and impeller had a similar change trend to the erosion wear deformation.