It has important guiding significance for the selection of technological parameters of negative pressure micro-irrigation for different crops, by understanding the characteristics of soil water movement under different combinations of technical parameters of negative pressure micro-irrigation. The soil water movement inversion model under negative pressure microirrigation based on HYDRUS-2D model was constructed and validated by parameter inversion based on the measured moisture data in the soil bin test. The combination of negative pressure micro-irrigation technical parameters suitable for different facility crops was explored by combining the simulation results of the inverse model for much wetter characteristics of negative pressure micro-irrigation and the root distribution characteristics and water demand pattern of typical facility crops. The results showed that the HYDRUS-2D inversion model can better simulate the characteristics of the soil wetter under different water supply heads of negative pressure micro-irrigation. The determination coefficients and NSE between simulated and measured values of soil wetting distance (horizontal distance, vertical upward distance and vertical downward distance), water content and cumulative infiltration reached above 0.98 and 0.77, respectively. Both experimental and simulation results showed that there was a negative correlation between the negative pressure of the water supply head and soil water content, the cumulative infiltration and wetting distance in different directions under negative pressure micro-irrigation conditions. In addition, a suitable range of technical parameters for negative pressure micro-irrigation for different facility crops was formulated, based on the simulation results of the inverse model for different wetting bodies of negative pressure micro-irrigation and the root distribution characteristics and water demand pattern of typical facility crops. These results were important for the selection of technical parameters for negative pressure micro-irrigation in agricultural production and the promotion of new water-saving irrigation techniques.