Aiming at the problems of no-tillage maize planting in drip irrigation area, the drip irrigation tape in narrow row is easy to entangle with straw, which affects the trafficability of no-till planter. The straw partition cleaning method suitable for no-tillage wide-narrow row in drip irrigation area was put forward, and the device for cleaning straw in sowing strip was designed, which adopted longitudinal dislocation arrangement straw cleaning mechanism to clean up straw in sowing strip. Based on the theoretical analysis of the interaction law between the key components and straw, key influencing factors and value ranges were determined. Based on the EDEM discrete element simulation technology, the working speed, soil contacting depth and the longitudinal spacing were selected as the influencing factors, and straw cleaning rate was selected as the response value for three factors and three levels sub-regression orthogonal test design. The regression equations to describe the relationships between the factors and straw cleaning rate were established by using the regression analysis and response surface analysis with the software Design-Expert 10.0.7. The optimum combination of the selected parameters was obtained, and the field test verification was also conducted. The results showed that the significant effects of working speed, the longitudinal spacing and soil contacting depth on cleaning rate were in a decreasing order. While the working speed was at 9km/h, the longitudinal spacing was 1100mm and soil contacting depth was 45mm, straw cleaning rate of the device was 87.61%, which was 1.8 percentage points lower than the theoretical value of model optimization. The cleaning width of sowing strip was ranged from 508.0mm to 540.4mm.