The harvesting flow chart and overall design of 4LQZ-6 tangential-longitudinal axial combine harvester was put forward and the design parameters of major working parts such as tangential axial threshing and separating unit, positive feeding unit, longitudinal axial threshing and separating unit and air-and-screen cleaning unit were discussed. The test in fields showed that when the wheat yield was 6605 kg/hm2, the total loss rate was 0.2%, breakage rate and rate of impurity were both 0.1%, productivity was 1.47hm2/h. When the rice yield was 8021kg/hm2, the total loss rate was 1.7%, breakage rate and rate of impurity were 0.9% and 0.8% respectively, productivity was 2.27hm2/h. The technical indexes could meet the demands of design.