How to meet the diverse requirements while keeping the low cost for product development and high efficiency is the main problem of designing reuse in mass customization. Based on the idea of “decreasing the internal diversity, increasing the external diversity” of mass customization, a “multi-view, multi-layer, multi-granularity” design reuse model was proposed. Both the practical and economical requirements of the product were encountered. Design reuse strategy for mass customization was studied and a combined strategy of product family, component modularization, part standardization, feature generalization was given. On one hand, the strategy ensured the economy of design reuse; on the other hand, the diverse requirements of customs were encountered commendably. Finally, the application instance was given; the software system was developed and applied. 