In order to solve the problem of massive deposition or blockage of particles in the labyrinth runner pressure-compensated irrigator to the extent of affecting the normal operation of the irrigator, after simulating the deformation of the fixed gasket by FSI, and based on the coupled simulation of CFD-DEM, and after verifying its reliability through experimental comparisons, the design of the one-factor and Box-Behnken response surface test was carried out to analyze the effects of the three structural parameters of the sub-runner cross-sectional area in the pressure-compensated chamber, the outlet diameter of the pressure-compensated chamber, the diameter of the pressure-compensated chamber and their interactions on the anti-clogging performance of the irrigator, and to make comprehensive judgments on the anti-clogging performance of the irrigator through the establishment of a regression model for the prediction of the particles retention rate in the irrigator. The results showed that the particle retention rate was decreased by 5-09 percentage points when the cross sectional area of the secondary flow channel was increased from 0.018mm2 to 0.054mm2; and the particle retention rate was decreased by 2.87 percentage points when the diameter of the pressure-compensated outlet was decreased from 1.4mm to 0.8mm. Particle deposition was significantly affected by two interactions, the cross-sectional area of the secondary flow channel and the outlet diameter of the pressure-compensated chamber, and the cross-sectional area of the secondary flow channel and the diameter of the pressure-compensated chamber, with the lowest particle retention rate of 7.67% under the interaction. The regression equations of particle retention rate and three structural parameters, namely, cross-sectional area of the secondary flow channel in the pressure-compensated chamber, outlet diameter of the pressure-compensated chamber, and diameter of the pressure-compensated chamber, were fitted, which can be used to judge and predict the anti-clogging performance of the irrigator, and a set of optimal anti-clogging parameters with a secondary flow channel area of 0.051mm2, an outlet diameter of the pressure-compensated chamber of 0.894mm, and a diameter of the pressure-compensated chamber of 6.923mm were recommended. In conclusion, by studying the clogging mechanism of the pressure-compensated irrigator, a judgment model that can predict the particle retention rate was established, which reduced the probability of clogging of the irrigator and improved its stable filling time, and provides theoretical support for the design of anti-clogging performance of this type of irrigator.