Based on the reasonable configuration and ventilation form of plastic greenhouse, so as to achieve effective cooling in summer, by way of actual observation and CFD model, the typical temperature field and air flow field of side opening greenhouse, roof plus side opening greenhouse, horizontal roll-up greenhouse and of vertical roll-up greenhouse during June and July were studied. The model was verified by actual measurement, and the simulated values were basically consistent with the measured value, with root mean square error (RMSE) of 1.27℃ and mean relative error (MRE) of 3.7%, respectively. According to the study, compared with side openings alone, roof plus side openings improved the cooling effect significantly, decreased the daily average temperature and heating rate of tomato canopy height by 0.4~2.1℃ and 0.4℃/h, respectively, increased the ventilation rate by 50%, and enhanced the temperature and air distribution uniformity. Compared with top horizontal roll-up shape, vertical rollup shape improved the cooling effect significantly, decreased the daily average temperature and heating rate of tomato canopy height by 0.2~1.2℃ and 0.2℃/h, respectively, increased the ventilation rate by 20%, but slightly reduced the temperature and air distribution uniformity. Comprehensive comparison showed that the plastic greenhouse with side opening and top vertical film rolling ventilation worked well in ventilation and cooling.