Anoplophora glabripennis is widely distributed in China as the main pest of forest trees, and the distribution area is constantly expanding. It is important to study the spatial correlation of insect infestation and analyze the factors that affect its distribution. Using geodetector, the effects of environmental factors on the Anoplophora glabripennis disaster were analyzed. The results showed that the most seriously damaged areas were in the northern part of Shanxi Province, while the incidence rates in Henan, Shandong, and southern Hebei were relatively low. The main meteorological factors affecting the spatial distribution of the incidence rate were precipitation and temperature, and the main social and economic factors were population and regional GDP. The effect of temperature on the value of the first and second industries was significantly different from that of other factors. Economic development had significant positive effect on the control of local insect pests. The interaction detection showed that the combination of any two variables can explain the spatial heterogeneity of Anoplophora glabripennis disaster more effectively. The interpretation ability of incidence rate was increased significantly after interaction between precipitation and control rate.