To analyze contribution and characteristics of interior hydrodynamic noise of the jetting centrifugal pump (JCP), the numerical calculation and experiment were carried out. Unsteady numerical calculation under different conditions were performed by using large eddy simulation (LES) method, and pressure fluctuation on the surfaces of flowing-passed components was exported as the dipole source. The flow-borne noise induced by different components of the pump was predicted by acoustic finite element method (FEM). Considering the coupling effect of sound and vibration, the weak coupling model of flow field, structure field and sound field was established to predict flow-induced structure noise generated from structural vibration. To obtain time and frequency domain information of the hydrodynamic noise in the pump outlet, a test-bed with hydrophone was built. The results showed that the maximum error between numerical calculation and experiment was 4% at major characteristic frequency. The rotor-stator interaction between impeller and vane as well as the resonance of fluid and structure was important factors of the interior noise of JCP, reflecting the structural characteristics of the flowing-passed components had some influence on the interior noise. Flow-borne noise of stators was generally greater than flow-induced structure noise, which proved interior noise was mainly determined by the pressure fluctuation characteristics of fluid. Numerical calculation and test results showed that the shaft frequency (47.5Hz) noise caused by the impeller had about 180dB and played a dominant role in the hydrodynamic noise of JCP, which provided reference and basis for hydraulic design of the low noise JCP.