The BRT_Dyna-CLUE_Patch-dynamics model was formed by improving Dyna-CLUE model, by embedding BRT model and Patch-dynamics model. Based on the landuse situation in Dengkou County in 2006, a case study was conducted in Dengkou County, a typical county in the ecologically fragile region. The BRT_Dyna-CLUE_Patch-dynamics model was used to simulate the landuse situation in 2016 in Dengkou County and compared with the Logistic_CA_Markov model which was currently used more. The results showed that the Kappa coefficient of the Logistic_CA_Markov model was 0.7214, and the Kappa coefficient of the BRT_Dyna-CLUE_Patch-dynamics model was 0.7826. The simulation results of the two combinatorial models were highly accurate and both were highly consistent with the real interpretation results. BRT_Dyna-CLUE_Patch-dynamics model had high simulation accuracy and good result. Therefore, it is feasible to apply the BRT_Dyna-CLUE_Patch-dynamics model to the simulation and forecast of local landuse change in order to provide some reference for the implementation of local ecological control and related policies.