A series of pressure fluctuation and vibration acceleration were measured at the key monitoring points under the speeds of 1450, 1200, 1000r/min, and their correlations were discussed. The experimental results showed that the peak to peak values of the pressure fluctuation didn’t obey the pump similarity law. The pressure fluctuation patterns were different under different rotating speeds. The maximum peak-to-peak value moved from the impeller inlet to the guide vane outlet with the rotating speed increased. The main frequency at impeller inlet was the blade passing frequency (BPF) under different rotating speeds, and the main frequency in impeller outlet and guide vane outlet were slightly lower than the blade passing frequency with rotating speed increased. The amplitude at the impeller outlet was increased firstly, and then decreased, while it was always increased at the guide vane outlet with rotating speed increased. The vibrations at different positions in the model pump mainly included shaft frequency which was induced by mass unbalance of rotor system and the low frequency induced by the unsteady fluid in pump. In the frequency ranged from about 0 to 2 times，the pressure pulsation and vibration tendency was substantially the same, and the speed variations had a similar effect on both of them. There were main 1~4 times rotation frequencies in pressure fluctuation frequency domain at different monitoring points, which were changed under different rotating speeds, while only 1 and 2 times of shaft rotation frequency played the main role in the vibration frequency domain at different monitoring locations.