A 3-D multiphase computational fluid dynamics model was used to study the coupling interaction of the natural wind, the air curtain and discrete droplets in the boom sprayer application and analyze the characteristics of air-assisted spray condition parameters on the boom spraying drift. The analytic results showed that increased outlet velocity of the air-assisted flow stressed droplet movement to target and then decreased the droplet deposition rate. Small nozzle flow rate implicated obvious loss trend of droplet drift. However, when the nozzle flow was excessive, the anti-drift loss of capacity of droplets decreased significantly. Air-assisted blowing angle had no significant impact on the drift reduction.