In view of the strong coupling between temperature and relative humidity in the greenhouse simulation system, an adaptive decoupling method based on dynamic matrix control was proposed. Taking the measure of feedforward compensation to eliminate interaction between channels of temperature and humidity, an adaptive decoupling algorithm by weighting was designed. The proposed method can adjust the decoupling parameters online under different operating modes, effectively overcome the effect of model severe mismatch to control accuracy. Compared with the traditional PID control, simulation and experimental results both indicated the proposed strategy greatly improved the control performance.