The catalytic removal function and mechanism of ultrasonic treatment coupling with TiO2 on pyrethroid pesticides in apple juice were investigated, the main quality change of apple juice and mechanism of catalytic removal were researched. The response surface method was applied to optimize the process parameters and the results were as follows: the TiO2 amount was 0.5g／L, the ultrasonic power was 416W, the treatment time was 18min, the ultrasonic temperature was 37℃. Under this condition, the removal rate would reach to 62.17%. The main chemical and physical indexes of apple juice processed by ultrasonic treatment coupling with TiO2 have no significant change, all accord with the export standards of apple juice.