The influence of offsets (-0.25mm, 0, 0.25mm, 0.50mm) of dental labyrinth channels of drip emitters on hydraulic and anti-clogging performance was studied by the following methods: there were numerical simulations carried out for the liquid-phase flow and the liquid-solid two-phase flows in the flow field by the CFD program Fluent, and the samples were tested. The obtained results showed positive relationship between offset and discharge coefficient, and negative relationship between offset and flow state exponent. With the increasing of the offset of emitters, the anti-clogging ability declined. Thus, combining the hydraulic and anti-clogging performance, under the condition of adequate flow state exponent, it put forward a suggestion that reducing the offset as much as possible to enhance the anti-clogging performance.