Development of the flow model of scalariform perforation plates was introduced from domestic country to foreign country. The mathematics model of scalariform perforation plates was established. The simulation model of the flow in the region of scalariform perforation plates with different structures was established through Fluent software.From calculating and analyzing the simulation result, the influences of inclination angle of perforation plates, inner diameter of vessel, hole number, equivalent hole width to flow resistance coefficient were studied. The results showed that when other parameters were initialized, with the indination angle increasing, average flow was invariant, the drop of pressure on both side of perforation plates and flow resistance coefficient decreased at the beginning, and increased later. With the value of inner diameter increasing, average flow increased, the drop of pressure and flow resistance coefficient decreased. With hole number increasing, average flow was invariant, the drop of pressure and flow resistance coefficient increased. With equivalent hole width increasing, average flow was invariant, the drop of pressure and flow resistance coefficient decreased.