Aiming at the structural characteristics and mission requirements of the intelligent vehicle, a navigation strategy was designed with respect both to architecture and information process. A hybrid architecture containing deliberation and reaction was proposed on the basis of multi-agent. A set of agents was designed according to the structural characteristics. Based on the previous research, the methods of image proceeding and information fusion were integrated into this architecture. The simulation and experiment results showed that the intelligent vehicle with the multi-agent architecture could use the information of multi-sensor efficiently and performed well on navigation and obstacle avoidance.