By using explicit dynamic simulation software ANSYS/LS-DYNA, the sugarcane-cutter system dynamics simulation model was established. The precision of the simulation model was verified by physical experiment. By using four-factor of second order general rotation composite design and the sugarcane-cutter system dynamics simulation model, the dynamics simulation of one-blade cutting sugarcane was carried out. The mathematical model of the influencing factors, cutting forces and shear stresses was established. The influence law of the factors and their interaction were analyzed, and the respective optimization of the factors was gained. The optimal cutting force interval with 95% reliability was obtained. The results showed that when knife-edge angle of blade is 17.5°, cutting angle of blade is 27.73°, obliquity of disc cutter is 28° and cutting velocity is 16m/s, the optimal cutting force interval with 95% reliability is from 235.82N to 297.98N.