To solve the shortage of freshwater resources in Huanghuaihai plain, salt stress experiments were carried out with different mineralization degrees slight saline water, the response of soil salt content of active rooting zone, yield and leaf area indexes to salt stress were analyzed. It showed that winter wheat has different responses under different rainfalls in growth duration. In order to obtain satisfactory yields, the highest degree of mineralization was 3g/L in wet years and general years under local soil conditions, while in the drought years, the highest degree of mineralization could be used was 2g/L without taking other measures. The results provided some basis for the rational development and use of local underground saline water resources.