1.19%。The influence of drying temperature and pressure in the chamber on the drying characteristics of vacuum drying on Cornus officinalis was studied. The regression mathematical models of drying time and content of loganin versus drying temperature and pressure were established. The optimal combination of the parameters for vacuum drying of Cornus officinalis was obtained through nonlinear optimization method with multiple targets. The results showed that the regression mathematical models agreed well with the experimental data, and under the conditions of drying temperature 68.1℃ and pressure 1kPa, the optimal integrative values were obtained as drying time 248min and content of loganin 1.19%, respectively.