A camera calibration method was put forward and applied to non-contacting detection for the front fender of a car. The spatial lattice has been constructed by using virtual target and the corner coordinates were extracted with SUSAN operator. In order to acquire the camera parameters, the corner coordinates have been brought into the camera model and the coordinates and error of these points were obtained. An iterative algorithm was presented to correct all the parameters till the error within the permission. The error compensation was performed by using tri-linear interpolation. The experiment showed that the method is rapid and has high stability and accuracy, and its precision is up to subpixel. 