With consideration of several different factors of loading direction, the moisture content and loading type and so on, the mechanical properties of Ginkgo seed nucleus were studied by way of compression test. The crushing forces of Ginkgo seed nucleus were different in each orientation under the same moisture content, which were smallest in width and greatest in thickness, respectively. Moisture content had a significant impact in the compression crash of seed nucleus. The more moisture content was, the less clearance occurred to shell and nutlet, thus crashing easily. The nutlet deformation was expanded while the moisture content of nutlet was high, but the crushing force of nutlet was less. The studies indicate that the crushing force is (135.82±24.48)N when Ginkgo seed nucleus has moisture content of 27.66%. The intact nutlet will be obtained when the displacement of the compression head toward the nutlet is up to (2.4±0.5)mm while the allowable nutlet deformation of 2.23 mm is not exceeded.