Orthogonal experiments were carried out to study the oxygen transfer performance of the dual laterolog aspirating aerator. The work has been focused on the improvement of oxygen-transfer power efficiency with respect to the varying of the aerator's major structural parameters. Effects of single and interaction among them of the four factors on oxygen-transfer power efficiency were investigated respectively. Meanwhile, optimal combination of the four factors on oxygen-transfer power efficiency was presented. It showed an appropriate combination of different factors may improve oxygen-transfer power efficiency effectively. The following summarized the detailed contributions that have been made in the research: ①Ranking of main structural parameters impacting power efficiency is as follows: the location coefficient, section ratio, nozzle angle and throat-pipe aspect ratio. ②Optimized structural parameters that were found in the research are the location coefficient R=0; section ratio m=4; nozzle angle a=30°; pipe aspect ratio β=10. ③There is significantly interactive effect between location coefficient and section ratio.