In order to study the extraction technology of isopropyl alcohol on soybean, a regression model of oil extraction rate was founded based on experimental data. The extraction process was simulated with the application of Matlab, and the influence of extraction parameters (temperature, pretreatment method, solvent/collet ratio, water content) on extraction rate was discussed. Meanwhile, the relation between extraction rate and oil diffusion coefficient in flake was analyzed, and the correlative extraction process parameters were determined.