This paper firstly analyzes the characteristics of gear-shifting rules for EQ6110 bus and performances of C220 diesel engine and vehicle prototype. Based on the AVL Cruise software, a simulation model for the bus is set up, and gear-shifting rules for the electric automatic manual transmission are also put forward. At last, the simulation results show that the fuel consumption of bus with the double parameters gear shifting rules was reduced to 2.4 L/(100 km) and the fuel-saving rate reached to 6.7% in comparison with that of the single parameter gear-shifting rules. The consistency between the simulation results and the experimental results proves that the gear shifting rules are correct and reliable.